Procurement Report: 2-Amino-6-methyl-5-nitropyridine

Product Category: Pharmaceutical and Agrochemical Intermediates (Pyridine Derivatives) CAS Number: 22280-62-2 Molecular Formula: C₆H₈N₃O₂ Molecular Weight: ~153.14 g/mol (Note: Isomeric variations exist, e.g., 3-nitro isomer MW is similar)

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1. Technical Specifications and Performance Metrics

Based on industry standards for high-purity pyridine intermediates, the procurement of 2-Amino-6-methyl-5-nitropyridine requires strict adherence to specific physical and chemical parameters to ensure downstream synthesis success.

• Purity (Assay): The standard commercial grade typically ranges from 95% to 98%. For pharmaceutical applications, a minimum of 97% is often required to minimize by-product formation in subsequent coupling reactions.
• Physical State: The substance appears as a light yellow crystalline solid.
• Melting Point: Typical melting point ranges between 153°C and 155°C. Deviations outside this range (e.g., <150°C or >158°C) may indicate significant impurities or isomeric contamination (e.g., the 3-nitro isomer).
• Solubility: Soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO); sparingly soluble in water.
• Stability: Stable under standard storage conditions but sensitive to strong reducing agents and strong oxidizers.

Actionable Recommendation: When evaluating vendor samples, request a Certificate of Analysis (COA) that explicitly lists the melting point range and HPLC purity. Do not accept materials with a melting point deviation greater than ±2°C from the 153–155°C range, as this often correlates with the presence of the 3-nitro isomer, which can alter reaction kinetics in final drug synthesis.

2. Industry Compliance and Quality Assurance

Procurement of this chemical intermediate necessitates a robust compliance framework, particularly given its classification as a pharmaceutical intermediate.

• Quality Management Systems: Reliable manufacturers operate under ISO 9001 certified quality systems. This ensures consistent batch-to-batch quality and traceability.
• Documentation Requirements: Every shipment must be accompanied by:
  • Certificate of Analysis (COA): Verifying assay, melting point, and impurity profiles.
  • Safety Data Sheet (SDS/MSDS): Detailing handling, storage, and emergency measures.
• Regulatory Alignment: The product must comply with relevant regional regulatory requirements for chemical intermediates. While specific drug approvals (e.g., FDA/EMA) apply to the final drug, the intermediate must meet GMP (Good Manufacturing Practice) guidelines if destined for human pharmaceutical use.
• Safety Handling: As a nitro-amine compound, it requires handling protocols regarding flammability and potential toxicity.

Actionable Recommendation: Prioritize suppliers who explicitly state compliance with ISO 9001 and can provide a full COA and SDS immediately upon request. For GMP-grade requirements, ensure the supplier's facility is audited or certified for pharmaceutical-grade production. Verify that the "EC NO" (European Community Number) is available if exporting to or from the EU.

3. Cost Efficiency and Integration Capabilities

The market for specialized pyridine derivatives is characterized by moderate pricing due to the complexity of synthesis and the niche nature of the application.

• Price Ranges: Market data indicates a typical B2B price range of $600 – $700 per 10g for high-purity (97%+) grades. Bulk pricing (kg quantities) typically offers a discount of 30–50% compared to gram-scale pricing, though exact volume discounts depend on the specific manufacturer's capacity.
• Minimum Order Quantity (MOQ): Typical MOQs for this specialized intermediate range from 10g to 100g for R&D samples, scaling to 1kg for pilot production.
• Lead Time: Standard lead times are typically 2 to 4 weeks for in-stock items. Custom synthesis or large bulk orders may extend to 6–8 weeks.
• Integration: The compound integrates seamlessly into standard organic synthesis workflows involving nucleophilic substitution or reductive amination. Its specific substitution pattern (2-amino, 6-methyl, 5-nitro) allows for precise regioselective reactions.

Actionable Recommendation: For cost efficiency, consolidate orders to meet the 1kg threshold if your R&D timeline allows, as the per-gram cost drops significantly. If immediate project timelines are critical, budget for the premium on 10g–100g "rush" orders. Always negotiate based on the total annual volume forecast rather than single-transaction pricing to secure better long-term rates.

4. Typical Use Cases

2-Amino-6-methyl-5-nitropyridine serves as a critical building block in the synthesis of complex heterocyclic compounds.

• Pharmaceutical Synthesis: Primarily used as an intermediate in the manufacture of active pharmaceutical ingredients (APIs), particularly those requiring a pyridine core with specific amino and nitro functionalities.
• Agrochemical Development: Utilized in the synthesis of fungicides and herbicides where pyridine derivatives provide specific biological activity profiles.
• Material Science: Potential application in the development of specialized dyes or organic electronic materials where the nitro-amino group facilitates specific electronic transitions.
• Research & Development: Essential for academic and industrial research into novel pyridine-based scaffolds and structure-activity relationship (SAR) studies.

Actionable Recommendation: Align procurement volumes with your specific synthesis stage. If you are in the early discovery phase, purchase small quantities (10g) to validate reaction conditions. Move to bulk procurement (1kg+) only after the synthetic route is validated and scaled, to minimize inventory holding costs and degradation risks.

5. Long-Term Planning Considerations

Strategic procurement of this intermediate requires monitoring market dynamics and supply chain resilience.

• Market Trends: There is a steady demand for pyridine-based intermediates driven by the global pharmaceutical pipeline. The specific substitution pattern (5-nitro) suggests a niche but stable demand, likely tied to specific drug classes.
• Supply Chain Risks: As a specialized chemical, supply is limited to a select number of manufacturers. Disruptions in raw material supply (e.g., specific nitration precursors) can impact lead times.
• Regulatory Shifts: Increasing global scrutiny on nitro-compounds may lead to stricter environmental or safety regulations in the future, potentially affecting manufacturing costs or availability.
• Inventory Strategy: Given the potential for shelf-life degradation (light yellow crystals may darken over time), maintain a "Just-in-Time" inventory model rather than stockpiling large quantities unless storage conditions are strictly controlled.

Actionable Recommendation: Develop a dual-sourcing strategy by identifying at least two qualified manufacturers with ISO 9001 certification to mitigate supply chain disruption risks. Monitor regulatory updates regarding nitro-pyridines in your target markets (EU, US, APAC) to anticipate potential compliance costs.

6. Special Product Recommendations

The following table compares 2-Amino-6-methyl-5-nitropyridine with its common isomeric variants to assist in selecting the correct specification for your synthesis needs.

| Product Type | Best-Fit Buyer | Key Specs | Risk Check | Procurement Advice | | :--- | :--- | :--- | :--- :--- | | 2-Amino-6-methyl-5-nitropyridine (CAS 22280-62-2) | API Manufacturers, Agrochem R&D | Purity: 97%+, MP: 153-155°C, Light Yellow Cryst. | Verify isomer purity (avoid 3-nitro contamination). | Request COA with HPLC chromatogram; confirm ISO 9001 status. | | 2-Amino-6-methyl-3-nitropyridine (CAS 21901-29-1) | Alternative Synthesis Routes | Purity: 95%+, MP: ~153-155°C (similar range) | High risk of confusion with 5-nitro isomer; different reactivity. | Explicitly verify CAS number; do not substitute without re-validating synthesis. | | Generic Pyridine Intermediates | General Lab Research | Purity: 90-95% | High impurity risk; inconsistent melting points. | Avoid for critical API synthesis; use only for preliminary screening. |

Actionable Recommendation: Strictly verify the CAS number (22280-62-2) before ordering. The 3-nitro isomer (21901-29-1) has similar physical properties but different chemical reactivity, which could lead to failed reactions or impure final products. Always cross-reference the COA with the specific CAS number provided in your purchase order.

7. Frequently Asked Questions (FAQ)

Q1: What is the typical purity level required for pharmaceutical synthesis? A: For pharmaceutical applications, a purity of 97% or higher is standard. Lower purity grades (95%) may be acceptable for agrochemical intermediates but require additional purification steps for drug synthesis.

Q2: How do I distinguish between the 5-nitro and 3-nitro isomers? A: While melting points are similar (approx. 153-155°C), the isomers have different chemical reactivities. The only reliable method is to verify the CAS number (22280-62-2 for 5-nitro) and review the HPLC purity profile in the COA.

Q3: What are the storage requirements for this compound? A: Store in a cool, dry place away from direct sunlight and moisture. The light yellow crystals should be kept in sealed containers to prevent degradation or color change.

Q4: Is this product suitable for GMP manufacturing? A: Yes, provided the manufacturer operates under an ISO 9001 quality system and can provide a GMP-compliant COA and SDS. You must verify the specific facility certification with the supplier.

Q5: What is the typical lead time for bulk orders (1kg+)? A: Typical lead times range from 6 to 8 weeks for bulk orders, depending on the manufacturer's current production schedule and raw material availability.

Q6: Can I expect price variations based on order volume? A: Yes. While 10g samples may cost around $632, bulk orders (1kg+) typically see a significant reduction in per-gram cost, often dropping by 30-50% compared to gram-scale pricing.

Q7: Are there any specific safety hazards associated with this chemical? A: As a nitro-amine compound, it requires standard safety precautions. Always consult the SDS for specific handling, fire-fighting, and first-aid measures. It is generally stable but should be kept away from strong reducing agents.

Q8: What documentation is mandatory for import/export? A: Mandatory documents include the Certificate of Analysis (COA), Safety Data Sheet (SDS), and commercial invoice. For international shipments, ensure the supplier provides the correct EC Number and HS Code for customs clearance.