Source Pharmaceutical Intermediate Quizartinib for Research

Quizartinib Sourcing Guide

Procuring Quizartinib requires precise identification of the specific chemical entity, as the market lists multiple distinct pharmaceutical intermediates with overlapping keywords. Buyers must verify the CAS number 950769-58-1 to ensure the material matches the intended therapeutic target, distinguishing it from other kinase inhibitors like Ponatinib or Ibrutinib which appear in the same catalog. The observed listings indicate a focus on white powder forms suitable for adult pharmaceutical applications, necessitating a rigorous check of the molecular formula C29H32N6O4S against the requested specification.

Sourcing decisions should prioritize suppliers who explicitly list the Grade as Pharmaceutical and provide a Test Method of HPLC for purity verification. The available data suggests a shelf life of two years for the specific Quizartinib variant, which impacts inventory planning and storage requirements. Buyers must confirm that the packaging, whether drums or vacuum-packed bags, maintains the integrity of the powder during transit to prevent degradation before the material reaches the manufacturing facility.

Product Scope and Observed Listing Signals

The current market signals reveal a diverse range of pharmaceutical intermediates, including Quizartinib, Ponatinib, and Cabozantinib, often grouped under broad keyword searches. While the core keyword focuses on Quizartinib, buyers must navigate listings that may also feature related compounds like Quinine or Erlotinib Hydrochloride, which share similar powder appearances and packaging formats. It is critical to isolate the specific product model, such as SWP A220-1, to avoid confusion with other models like SWP A220 that may correspond to different chemical entities or purity levels.

Observations indicate that customization is available for many of these intermediates, allowing for tailored packaging standards like 5 g/bag or 1kg foil bags. However, the Minimum Order Quantity (MOQ) varies significantly across the catalog, ranging from small 5-gram samples to bulk 1-kilogram orders. Buyers should align their procurement volume with the specific MOQ of the verified Quizartinib listing to avoid unnecessary costs or supply chain bottlenecks associated with mismatched order sizes.

Technical Specifications to Verify

Technical verification begins with confirming the molecular weight of 560.67 and the exact CAS number 950769-58-1 to ensure chemical identity. The product appearance is consistently described as a white powder, but buyers must demand batch-specific test reports to validate this physical characteristic against the stated purity of greater than 99%. Relying solely on general descriptions is insufficient; the HPLC test method must be explicitly cited in the certificate of analysis to guarantee the absence of impurities that could compromise downstream synthesis.

Packaging specifications are equally critical, with options ranging from vacuum-packed drums to vials depending on the supplier's standard. The observed standards include 5 g/bag or 99% purity benchmarks, yet these values must be cross-referenced with the specific batch documentation provided. Buyers should verify that the product origin, whether from Shaanxi or Fujian, aligns with their regulatory requirements for manufacturing sites, as regional differences can influence the consistency of the pharmaceutical grade material.

Compliance and Safety Documentation

Compliance documentation must explicitly list certifications such as BP, USP, ISO HSE, and GMP to meet international regulatory standards. The presence of these certifications indicates a supplier's adherence to quality management systems, but buyers must request current, batch-specific certificates rather than relying on general company claims. The distinction between "Pharmaceutical" and "Pharmaceutical Grade" is subtle but important, and the documentation must clearly state which classification applies to the specific Quizartinib batch being purchased.

Safety data sheets and handling protocols are essential for managing the white powder form, which requires specific storage conditions to maintain its two-year shelf life. Buyers should verify that the supplier provides clear instructions for the 5 g/bag or 1kg foil bag packaging to ensure safe transport and storage. Additionally, the suitability for adult use must be confirmed in the product documentation, as some listings may include broader categories like children or elderly that do not apply to the specific intermediate being sourced.

Cost Drivers and Commercial Terms

Cost drivers in this sector are heavily influenced by the Minimum Order Quantity and the specific packaging requirements chosen by the buyer. The observed price range spans from 0.1 to 1900 USD, reflecting the variability between small sample orders and bulk pharmaceutical-grade purchases. Buyers must clarify whether the quoted price includes the cost of specialized packaging, such as vacuum packing or foil bags, as these can significantly impact the total landed cost of the material.

Commercial terms regarding lead times and shipping origins, such as Shaanxi or Fujian, China, must be negotiated explicitly to avoid delays. The availability of customization options may introduce additional costs or extended lead times, which should be factored into the procurement timeline. Buyers should ensure that the agreed-upon standard, whether 5 g/bag or 99% purity, is clearly defined in the purchase order to prevent disputes over the final delivered product specifications.

Supplier Qualification and Quality Control

Supplier qualification requires a thorough review of their quality control processes, specifically their use of HPLC for testing and their adherence to GMP standards. The ability to provide customized solutions suggests a flexible manufacturing process, but this flexibility must not come at the expense of consistent quality. Buyers should verify that the supplier maintains a robust system for tracking the shelf life of their products, ensuring that the material delivered is well within the two-year or three-year validity period.

Quality control checks must extend to the physical appearance and molecular integrity of the white powder. The supplier should be able to demonstrate that the product model, such as SWP A220-1, consistently meets the specified molecular formula and weight. Regular audits of the supplier's facilities, particularly those in Shaanxi or Fujian, can provide assurance that the pharmaceutical grade material is produced under controlled conditions that minimize the risk of contamination or specification drift.

Long-Term Procurement Checks

Long-term procurement strategies should focus on maintaining a stable supply chain for Quizartinib by establishing clear communication channels with qualified suppliers. Buyers must regularly review the supplier's certification status to ensure continued compliance with BP, USP, and ISO standards, as these can change over time. Proactive monitoring of the shelf life and storage conditions of the inventory is essential to prevent the use of degraded material in critical pharmaceutical applications.

Continuous verification of the product specifications, including the CAS number and purity levels, is necessary to adapt to any changes in regulatory requirements or manufacturing processes. Buyers should maintain a database of historical test results to identify trends in quality or consistency. By keeping a close watch on the commercial terms and MOQ adjustments, organizations can optimize their procurement costs while ensuring a reliable supply of high-quality pharmaceutical intermediates for their production needs.